What Will the OECD BEPS Indicators Indicate?

What do shifts in indicators of apoptosis indicate about the cancer process?

Overview Apoptosis is genetically programmed cell death (1). It is defined by specific morphological criteria whose hallmark is condensation and fragmentation of the cell nucleus with endonuclease cleavage of DNA, but it is mediated by more than 1 biochemical pathway. The 2 major pathways of apoptotic cell death are the intrinsic or mitochondrial pathway and the extrinsic pathway, which is depe...

Climate Change or Land Use Dynamics: Do We Know What Climate Change Indicators Indicate?

Different components of global change can have interacting effects on biodiversity and this may influence our ability to detect the specific consequences of climate change through biodiversity indicators. Here, we analyze whether climate change indicators can be affected by land use dynamics that are not directly determined by climate change. To this aim, we analyzed three community-level indic...

Hourly rounds: what does the evidence indicate?

Hourly rounds—intentionally checking on patients at regular intervals—continues to be debated in nursing circles. Often, registered nurses make rounds on even hours and support staff make rounds on odd hours from 6 AM to 10 PM (and every 2 hours from 10 PM to 6 AM). While making rounds, staff engage patients by checking on the “4 P’s”: pain, positioning, potty (elimination), and proximity of pe...

Preventing suicide: what will work and what will not.

What Will Probably Happen